Journal article
The role of exhaustion in CAR T cell therapy
GM Delgoffe, C Xu, CL Mackall, MR Green, S Gottschalk, DE Speiser, D Zehn, PA Beavis
Cancer Cell | Published : 2021
Abstract
CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.